{PDOC00766}
{PS00999; SSI}
{BEGIN}
*****************************************************
* Streptomyces subtilisin-type inhibitors signature *
*****************************************************

Bacteria of the Streptomyces family produce  a family of proteinase inhibitors
[1] characterized  by  their  strong  activity  toward  subtilisin.  They  are
collectively known  as  SSI's:  Streptomyces Subtilisin Inhibitors. Some SSI's
also inhibit trypsin or chymotrypsin. In their mature secreted form, SSI's are
proteins of about 110 residues with two conserved disulfide bonds.

                       +-------+         +--------------+
                       |       |         |              |
         xxxxxxxxxxxxxxCxxxxxxxCxxxxxxxxxCx#xxxxxxxxxxxxCxxxxxx
                       ************

'C': conserved cysteine involved in a disulfide bond.
'#': active site residue.
'*': position of the pattern.

-Consensus pattern: C-x-P-x(2,3)-G-x(0,1)-H-[PA]-x(4)-A-C-[ATDE]-x-L
                    [The 2 C's are involved in a disulfide bond]
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: April 2006 / Pattern revised.

[ 1] Taguchi S., Kojima S., Terabe M., Miura K.-I., Momose H.
     "Comparative studies on the primary structures and inhibitory
     properties of subtilisin-trypsin inhibitors from Streptomyces."
     Eur. J. Biochem. 220:911-918(1994).
     PubMed=8143745

--------------------------------------------------------------------------------
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and
distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives
(CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html
--------------------------------------------------------------------------------

{END}