{PDOC00771}
{PS01008; DNAA}
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* DnaA protein signature *
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The bacterial  dnaA  protein [1,2,3] plays an important role in initiating and
regulating chromosomal  replication.  DnaA is an ATP- and DNA-binding protein.
It binds specifically to 9 bp nucleotide repeats known as dnaA boxes which are
found in the chromosome origin of replication (oriC).

DnaA is  a  protein  of  about  50 Kd that contains two conserved regions: the
first is  located  in  the  N-terminal half and corresponds to the ATP-binding
domain, the  second is located in the C-terminal half and could be involved in
DNA-binding. We  used  the  most  conserved  part  of the putative DNA-binding
domain as a signature pattern.

-Consensus pattern: [IL]-[GA]-x(2)-[LIVMF]-[SGADENK]-x(0,1)-[KR]-x-H-[STPA]-
                    [STAV]-[LIVM]-x(2)-[SGAMN]-x(3)-[LIVM]
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: December 2004 / Pattern and text revised.

[ 1] Skarstad K., Boye E.
     "The initiator protein DnaA: evolution, properties and function."
     Biochim. Biophys. Acta 1217:111-130(1994).
     PubMed=8110826
[ 2] Yoshikawa H., Ogasawara N.
     "Structure and function of DnaA and the DnaA-box in eubacteria:
     evolutionary relationships of bacterial replication origins."
     Mol. Microbiol. 5:2589-2597(1991).
     PubMed=1779750
[ 3] Georgopoulos C.
     "The E. coli dnaA initiation protein: a protein for all seasons."
     Trends Genet. 5:319-321(1989).
     PubMed=2558436

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