{PDOC00774} {PS01013; OSBP} {BEGIN} ********************************************** * Oxysterol-binding protein family signature * ********************************************** A number of eukaryotic proteins that seem to be involved with sterol synthesis and/or its regulation have been found [1] to be evolutionary related: - Mammalian oxysterol-binding protein (OSBP). A protein of about 800 amino- acid residues that binds a variety of oxysterols: oxygenated derivatives of cholesterol. OSBP seems to play a complex role in the regulation of sterol metabolism. - Mammalian OSBP-related proteins 1 to 11. - Yeast proteins HES1 and KES1; highly related proteins of 434 residues that seem to play a role in ergosterol synthesis. - Yeast OSH1 to OSH7. All these proteins contain a moderately conserved domain of about 250 residues located in the C-terminal half of OBSP, OSH1 and YHR073w and in the central section of the other proteins. As a signature pattern, we selected the best conserved part of this domain, a region that contains a conserved pentapeptide. -Consensus pattern: E-[KQ]-x-[SC]-H-[HR]-[PG]-[PL]-x(1,2)-[STACFI]-[ACGY] -Sequences known to belong to this class detected by the pattern: ALL. -Other sequence(s) detected in Swiss-Prot: NONE. -Last update: April 2006 / Pattern revised. [ 1] Jiang B., Brown J.L., Sheraton J., Fortin N., Bussey H. "A new family of yeast genes implicated in ergosterol synthesis is related to the human oxysterol binding protein." Yeast 10:341-353(1994). PubMed=8017104 -------------------------------------------------------------------------------- PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html -------------------------------------------------------------------------------- {END}