{PDOC00784}
{PS01022; PTR2_1}
{PS01023; PTR2_2}
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* PTR2 family proton/oligopeptide symporters signatures *
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A family  of  eukaryotic  and  prokaryotic  proteins  that  seem  to be mainly
involved in  the  intake  of  small  peptides with the concomitant uptake of a
proton has  been  recently  characterized  [1,2]. Proteins that belong to this
family are:

 - Fungal peptide transporter PTR2.
 - Mammalian intestine proton-dependent oligopeptide transporter PeptT1.
 - Mammalian kidney proton-dependent oligopeptide transporter PeptT2.
 - Drosophila opt1.
 - Arabidopsis thaliana  peptide transporters PTR2-A and PTR2-B (also known as
   the histidine transporting protein NTR1).
 - Arabidopsis thaliana proton-dependent nitrate/chlorate transporter CHL1.
 - Lactococcus proton-dependent di- and tri-peptide transporter dtpT.
 - Caenorhabditis elegans hypothetical protein C06G8.2.
 - Caenorhabditis elegans hypothetical protein F56F4.5.
 - Caenorhabditis elegans hypothetical protein K04E7.2.
 - Escherichia coli hypothetical protein ybgH.
 - Escherichia coli hypothetical protein ydgR.
 - Escherichia coli hypothetical protein yhiP.
 - Escherichia coli hypothetical protein yjdL.
 - Bacillus subtilis hypothetical protein yclF.

These integral   membrane   proteins   are   predicted   to   comprise  twelve
transmembrane regions.  As  signature  patterns,  we  selected two of the best
conserved regions. The first is a region that includes the end of  the  second
transmembrane  region,  a cytoplasmic  loop as well as the third transmembrane
region.  The second pattern corresponds to the core of the fifth transmembrane
region.

-Consensus pattern: [GA]-[GAS]-[LIVMFYWA]-[LIVM]-[GAS]-D-x-[LIVMFYWT]-
                    [LIVMFYW]-G-x(3)-[TAV]-[IV]-x(3)-[GSTAV]-x-[LIVMF]-x(3)-
                    [GA]
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Consensus pattern: [FYT]-x(2)-[LMFY]-[FYV]-[LIVMFYWA]-x-[IVG]-N-[LIVMAG]-G-
                    [GSA]-[LIMF]
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: 1.

-Expert(s) to contact by email:
           Steiner H.-Y.; steinerh@am.abru.cg.com
           Becker J.M.; jbecker@utkvx.utk.edu

-Last update: November 1997 / Patterns and text revised.

[ 1] Paulsen I.T., Skurray R.A.
     "The POT family of transport proteins."
     Trends Biochem. Sci. 19:404-404(1994).
     PubMed=7817396
[ 2] Steiner H.-Y., Naider F., Becker J.M.
     "The PTR family: a new group of peptide transporters."
     Mol. Microbiol. 16:825-834(1995).
     PubMed=7476181

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