{PDOC00806}
{PS01049; YJEF_C_1}
{PS01050; YJEF_C_2}
{PS51383; YJEF_C_3}
{BEGIN}
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* YjeF C-terminal domain signatures and profile *
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The YjeF  C-terminal  domain  is an ~280-residue module found in the following
proteins:

 - Yeast chromosome XI hypothetical protein YKL151c.
 - Caenorhabditis elegans hypothetical protein R107.2.
 - Escherichia coli hypothetical protein YjeF.
 - Bacillus subtilis hypothetical protein yxkO.
 - Helicobacter pylori hypothetical protein HP1363.
 - Mycobacterium tuberculosis hypothetical protein MtCY77.05c.
 - Mycobacterium leprae hypothetical protein B229_C2_201.
 - Synechocystis strain PCC 6803 hypothetical protein sll1433.
 - Methanococcus jannaschii hypothetical protein MJ1586.
 - Streptococcus mutans putative uncharacterized protein SMU.573.
 - Streptococcus thermophilus predicted sugar kinase STER_0661.
 - Streptococcus sanguinis putative uncharacterized protein SSA_0673.
 - Thermotoga maritima hypothetical protein Tm0922.

The YjeF  C-terminal  domain  has an alpha/beta fold and shows high structural
homology to  the  members of a ribokinase-like superfamily. The members of the
ribokinase-like superfamily  are  all  phosphotransferases  and  catalyze  the
phosphorylation of the hydroxymethyl group of the substrate; magnesium and ATP
(or ADP)  are  required  for  their  activity. The YjeF C-terminal is found in
association with  the  YjeF  N-terminal domain, which belongs of a specialized
family of Rossmann fold domains (see <PDOC51385>) [1-3].

The first  pattern  we  developed  covers  residues  that might be involved in
forming the  substrate-binding  pocket. The second one corresponds to residues
that could form a kinase anion hole, with the conserved aspartate predicted to
be the  catalytic  base  [1].  We  also  developed  a profile which covers the
entire YjeF C-terminal domain.

-Consensus pattern: [SAV]-[IVW]-[LVA]-[LIV]-G-[PNS]-G-L-[GP]-x-[DENQT]
-Sequences known to belong to this class detected by the pattern: ALL, except
 for H.pylori HP1363.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Consensus pattern: [GA]-G-x-G-D-[TV]-[LT]-[STA]-G-x-[LIVM]
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Last update: May 2008 / Text revised; profile added.

[ 1] Zhang R.-G., Grembecka J., Vinokour E., Collart F., Dementieva I.,
     Minor W., Joachimiak A.
     "Structure of Bacillus subtilis YXKO--a member of the UPF0031 family
     and a putative kinase."
     J. Struct. Biol. 139:161-170(2002).
     PubMed=12457846
[ 2] Zhou Y.-F., Li L.-F., Yang C., Liang Y.-H., Su X.-D.
     "Preliminary X-ray crystallographic analysis of SMU.573, a putative
     sugar kinase from Streptococcus mutans."
     Acta Crystallogr. F 64:47-49(2008).
     PubMed=18097102; DOI=10.1107/S1744309107065645
[ 3] Anantharaman V., Aravind L.
     "Novel conserved domains in proteins with predicted roles in
     eukaryotic cell-cycle regulation, decapping and RNA stability."
     BMC Genomics 5:45-45(2004).
     PubMed=15257761; DOI=10.1186/1471-2164-5-45

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