{PDOC00815}
{PS01064; PYRIDOX_OXIDASE}
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* Pyridoxamine 5'-phosphate oxidase signature *
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Pyridoxamine 5'-phosphate oxidase (EC 1.4.3.5) is a FMN  flavoprotein involved
in the de novo synthesis  of pyridoxine (vitamin B6) and  pyridoxal phosphate.
It oxidizes  pyridoxamine-5-P (PMP) and pyridoxine-5-P (PNP) to pyridoxal-5-P.
The sequences of the enzyme from bacterial (genes pdxH or fprA) [1] and fungal
(gene PDX3)  [2]  sources  show  that  this  protein has been highly conserved
throughout evolution.

PdxH is  evolutionary  related  [3]  to  one  of  the enzymes in the phenazine
biosynthesis protein pathway, phzD (also known as phzG).

As a  signature  pattern, we selected a highly conserved region located in the
C-terminal part of these enzymes.

-Consensus pattern: [LIVFMYWA]-E-F-W-[QHGENRAMVYLCF]-x(4)-[RW]-[LIVMK]-[HN]-
                    [DNESIT]-R
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: April 2006 / Pattern revised.

[ 1] Lam H.-M., Winkler M.E.
     "Characterization of the complex pdxH-tyrS operon of Escherichia coli
     K-12 and pleiotropic phenotypes caused by pdxH insertion mutations."
     J. Bacteriol. 174:6033-6045(1992).
     PubMed=1356963
[ 2] Loubbardi A., Marcireau C., Karst F., Guilloton M.
     "Sterol uptake induced by an impairment of pyridoxal phosphate
     synthesis in Saccharomyces cerevisiae: cloning and sequencing of the
     PDX3 gene encoding pyridoxine (pyridoxamine) phosphate oxidase."
     J. Bacteriol. 177:1817-1823(1995).
     PubMed=7896706
[ 3] Pierson L.S. III, Gaffney T., Lam S., Gong F.
     "Molecular analysis of genes encoding phenazine biosynthesis in the
     biological control bacterium. Pseudomonas aureofaciens 30-84."
     FEMS Microbiol. Lett. 134:299-307(1995).
     PubMed=8586283

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