{PDOC00818} {PS01067; SECE_SEC61G} {BEGIN} ************************************** * Protein secE/sec61-gamma signature * ************************************** In bacteria, the secE protein plays a role in protein export; it is one of the components - with secY (see ) and secA - of the preprotein translocase. In eukaryotes, the evolutionary related protein sec61-gamma plays a role in protein translocation through the endoplasmic reticulum; it is part of a trimeric complex that also consist of sec61-alpha and beta [1]. Both secE and sec61-gamma are small proteins of about 60 to 90 amino acids that contain a single transmembrane region at their C-terminal extremity (Escherichia coli secE is an exception, in that it possess an extra N-terminal segment of 60 residues that contains two additional transmembrane domains). The sequence of secE/sec61-gamma is not extremely well conserved, however it is possible to derive a signature pattern centered on a conserved proline located 10 residues before the beginning of the transmembrane domain. -Consensus pattern: [LIVMFY]-x-{D}-[DENQGA]-x-{E}-x(2)-[LIVMFTA]-x-[KRV]-x(2)- [KW]-P-x(3)-[SEQ]-x(5)-{D}-{CG}-[LIVT]-[LIVGA]-[LIVFGAST] -Sequences known to belong to this class detected by the pattern: ALL. -Other sequence(s) detected in Swiss-Prot: 4. -Last update: April 2006 / Pattern revised. [ 1] Hartmann E., Sommer T., Prehn S., Goerlich D., Jentsch S., Rapoport T.A. "Evolutionary conservation of components of the protein translocation complex." Nature 367:654-657(1994). PubMed=8107851; DOI=10.1038/367654a0 -------------------------------------------------------------------------------- PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html -------------------------------------------------------------------------------- {END}