{PDOC00826}
{PS01075; ACETATE_KINASE_1}
{PS01076; ACETATE_KINASE_2}
{BEGIN}
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* Acetate and butyrate kinases family signatures *
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The following enzymes have been shown [1,2] to be evolutionary related:

 - Acetate  kinase  (EC  2.7.2.1)  (acetokinase) (gene ackA) from bacteria and
   archaebacteria. This enzyme  is  involved in the interconversion of acetate
   and acetyl-CoA  via  the acetyl phosphate intermediate. In anaerobic growth
   it provides ATP by catabolyzing acetate phosphate into acetate.
 - Butyrate  kinase  (EC  2.7.2.7) (gene buk). This enzyme  is involved in the
   interconversion of  butyrate  and  butyryl-CoA  via  the  butyryl phosphate
   intermediate.  Butyrate kinase  is  involved  in  the  acidogenic  phase of
   fermentation.
 - Propionate kinase (EC 2.7.2,.) (gene tdcD) from Escherichia coli.

We have developed two signature  patterns for these enzymes;  the first one is
located in the N-terminal section and the second in the central section.  Both
of them are glycine-rich and could be involved in substrate or ATP-binding.

-Consensus pattern: [LIVMFANT]-[LIVM]-x-[LIVMA]-N-x-G-S-[ST](2)-x-[KE]
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Consensus pattern: [LIVMFATQ]-[LIVMA]-x(2)-H-x-G-x-[GT]-x-[ST]-[LIVMA]-x-
                    [TAVC]-x(3)-G
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Last update: December 2004 / Pattern and text revised.

[ 1] Grundy F.J., Waters D.A., Allen S.H.G., Henkin T.M.
     "Regulation of the Bacillus subtilis acetate kinase gene by CcpA."
     J. Bacteriol. 175:7348-7355(1993).
     PubMed=8226682
[ 2] Oultram J.D., Burr I.D., Elmore M.J., Minton N.P.
     "Cloning and sequence analysis of the genes encoding
     phosphotransbutyrylase and butyrate kinase from Clostridium
     acetobutylicum NCIMB 8052."
     Gene 131:107-112(1993).
     PubMed=8396545

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