{PDOC00828}
{PS01078; MOCF_BIOSYNTHESIS_1}
{PS01079; MOCF_BIOSYNTHESIS_2}
{BEGIN}
********************************************************
* Molybdenum cofactor biosynthesis proteins signatures *
********************************************************

Eukaroytic and  prokaryotic  molybdoenzymes  require  a molybdopterin cofactor
(MoCF) for  their  activity.  The  biosynthesis  of  this  cofactor involves a
complex multistep  enzymatic  pathway. One of the eukaryotic proteins involved
in this pathway is the Drosophila protein cinnamon [1] which is highly similar
to gephyrin, a rat microtubule-associated protein  which was thought to anchor
the glycine  receptor  to  subsynaptic microtubules. Cinnamon and gephyrin are
evolutionary related,  in their  N-terminal half, to the Escherichia coli MoCF
biosynthesis proteins  mog/chlG  and moaB/chlA2 and, in their C-terminal half,
to Escherichia coli moeA/chlE.

As signature  patterns,  we selected two conserved regions: one located in the
N-terminal half, the other in the C-terminal half.

-Consensus pattern: [LIVMCA]-[LIVM](2)-[LITF]-[LITN]-G-G-T-G-x(4)-D
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Consensus pattern: S-x-[GS]-x(2)-D-x(5)-[LIVW]-x(10,12)-[LIV]-x(2)-[KR]-P-G-
                    [KRL]-P-x(2)-[LIVMF]-[GA]
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Last update: December 2004 / Pattern and text revised.

[ 1] Kamdar K.P., Shelton M.E., Finnerty V.
     "The Drosophila molybdenum cofactor gene cinnamon is homologous to
     three Escherichia coli cofactor proteins and to the rat protein
     gephyrin."
     Genetics 137:791-801(1994).
     PubMed=8088525

--------------------------------------------------------------------------------
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and
distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives
(CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html
--------------------------------------------------------------------------------

{END}