{PDOC00837} {PS01092; ADENYLATE_CYCLASE_1_1} {PS01093; ADENYLATE_CYCLASE_1_2} {BEGIN} **************************************** * Adenylate cyclase class-I signatures * **************************************** Adenylate cyclase (EC 4.6.1.1) is the enzyme responsible for the synthesis of cAMP from ATP. From sequence data, it has been proposed [1,2] that there are three different classes of adenylate cyclases. Class I cyclases are found in enterobacteria and related Gram-negative bacteria. They are proteins of about 850 residues that consist of two functional domains: a N-terminal catalytic domain and a C-terminal regulatory domain. As signature patterns we selected two highly conserved regions, the first one is located in the catalytic domain and the second one in the regulatory domain. The second signature includes a conserved histidine which could be phosphorylated by a PTS system IIA enzyme, thus leading to the activation of the cyclase. -Consensus pattern: E-Y-F-G-[SA](2)-L-W-x-L-Y-K -Sequences known to belong to this class detected by the pattern: ALL. -Other sequence(s) detected in Swiss-Prot: NONE. -Consensus pattern: Y-R-N-x-W-[NS]-E-[LIVM]-R-T-L-H-F-x-G [H could be phosphorylated] -Sequences known to belong to this class detected by the pattern: ALL. -Other sequence(s) detected in Swiss-Prot: NONE. -Expert(s) to contact by email: Danchin A.; adanchin@pasteur.fr -Last update: November 1997 / Pattern and text revised. [ 1] Danchin A. "Phylogeny of adenylyl cyclases." Adv. Second Messenger Phosphoprotein Res. 27:109-162(1993). PubMed=8418825 [ 2] Barzu O., Danchin A. "Adenylyl cyclases: a heterogeneous class of ATP-utilizing enzymes." Prog. Nucleic Acid Res. Mol. Biol. 49:241-283(1994). PubMed=7863008 -------------------------------------------------------------------------------- PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html -------------------------------------------------------------------------------- {END}