{PDOC00844}
{PS01100; NNMT_PNMT_TEMT}
{BEGIN}
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* NNMT/PNMT/TEMT family of methyltransferases signature *
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The following   cytoplasmic  vertebrate  methyltransferases  are  evolutionary
related [1,2]:

 - Nicotinamide N-methyltransferase (EC 2.1.1.1) (NNMT). NNMT catalyzes the N-
   methylation of  nicotinamide  and  other pyridines to form pyridinium ions.
   This activity  is  important  for  the  biotransformation of many drugs and
   xenobiotic compounds.
 - Phenylethanolamine N-methyltransferase (EC 2.1.1.28) (PNMT). PNMT catalyzes
   the last step in catecholamine biosynthesis, the conversion of noradrenalin
   to adrenalin.
 - Indolethylamine N-methyltransferase (EC 2.1.1.49) (INMT).
 - Thioether  S-methyltransferase  (EC  2.1.1.96)  (TEMT).  TEMT catalyzes the
   methylation of dimethyl sulfide into trimethylsulfonium.

These enzymes  use  S-adenosyl-L-methionine  as  the  methyl  donor.  They are
proteins of 30 to 32 Kd. As a signature pattern we selected the most conserved
region, a  stretch  of 16 residues which are located in the N-terminal section
of these enzymes.

-Consensus pattern: L-I-D-I-G-S-G-P-T-[IV]-Y-Q-[LV]-L-[SA]-A-C
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: December 2001 / Pattern and text revised.

[ 1] Aksoy S., Szumlanski C.L., Weinshilboum R.M.
     "Human liver nicotinamide N-methyltransferase. cDNA cloning,
     expression, and biochemical characterization."
     J. Biol. Chem. 269:14835-14840(1994).
     PubMed=8182091
[ 2] Thompson M.A., Moon E., Kim U.-J., Xu J., Siciliano M.J.,
     Weinshilboum R.M.
     "Human indolethylamine N-methyltransferase: cDNA cloning and
     expression, gene cloning, and chromosomal localization."
     Genomics 61:285-297(1999).
     PubMed=10552930; DOI=10.1006/geno.1999.5960

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