{PDOC00854}
{PS01110; RNA_POL_H_23KD}
{BEGIN}
************************************************
* RNA polymerases H / 23 Kd subunits signature *
************************************************

In eukaryotes,   there   are   three  different  forms  of  DNA-dependent  RNA
polymerases (EC 2.7.7.6)  transcribing different sets of genes.  Each class of
RNA polymerase  is  an assemblage of ten to twelve different polypeptides.  In
archaebacteria, there  is generally a single form of RNA polymerase which also
consist of an oligomeric assemblage of 10 to 13 polypeptides.

Archaebacterial subunit H (gene rpoH) [1,2] is a small protein of about 8.5 to
10 Kd,  it is evolutionary related to the C-terminal part of a 23 Kd component
shared by  all  three  forms of eukaryotic RNA polymerases (gene RPB5 in yeast
and POLR2E in mammals).

As a signature pattern we selected a conserved  region which is located at the
N-terminal extremity  of  subunit  H; this region contains two histidines that
could play a role in the binding of a metal ion.

-Consensus pattern: H-[NQEIVMYD]-[LIVMYAS]-V-P-[EKT]-H-x(2)-[LIVM]-x(2)-
                    [DESAG]-[ET]
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: December 2004 / Pattern and text revised.

[ 1] Klenk H.-P., Palm P., Lottspeich F., Zillig W.
     "Component H of the DNA-dependent RNA polymerases of Archaea is
     homologous to a subunit shared by the three eucaryal nuclear RNA
     polymerases."
     Proc. Natl. Acad. Sci. U.S.A. 89:407-410(1992).
     PubMed=1729711
[ 2] Thiru A., Hodach M., Eloranta J.J., Kostourou V., Weinzierl R.O.,
     Matthews S.
     "RNA polymerase subunit H features a beta-ribbon motif within a novel
     fold that is present in archaea and eukaryotes."
     J. Mol. Biol. 287:753-760(1999).
     PubMed=10191143

--------------------------------------------------------------------------------
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and
distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives
(CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html
--------------------------------------------------------------------------------

{END}