{PDOC00860}
{PS01116; XANTH_URACIL_PERMASE}
{BEGIN}
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* Xanthine/uracil permeases family signature *
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The following transport proteins  which are involved in the uptake of xanthine
or uracil are evolutionary related [1]:

 - Uric uric acid-xanthine permease (gene uapA) from Aspergillus nidulans.
 - Purine permease (gene uapC) from Aspergillus nidulans.
 - Xanthine permease from Bacillus subtilis (gene pbuX).
 - Uracil  permease  from  Escherichia coli (gene uraA) [2] and Bacillus (gene
   pyrP).
 - Hypothetical protein ycdG from Escherichia coli.
 - Hypothetical protein ygfO from Escherichia coli.
 - Hypothetical protein ygfU from Escherichia coli.
 - Hypothetical protein yicE from Escherichia coli.
 - Hypothetical protein yunJ from Bacillus subtilis.
 - Hypothetical protein yunK from Bacillus subtilis.

They are  proteins  of  from  430  to  595  residues  that  seem to contain 12
transmembrane domains. As a signature pattern, we  selected the best conserved
region which  corresponds  with  what  seems  to  be  the  tenth transmembrane
domain.

-Consensus pattern: [LIVM]-P-x-[PASIF]-V-[LIVMG]-[GF]-[GA]-x(4)-[LIVM]-[FY]-
                    [GSA]-x-[LIVM]-x(3)-[GA]
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: December 2004 / Pattern and text revised.

[ 1] Diallinas G., Gorfinkiel L., Arst H.N. Jr., Cecchetto G., Scazzocchio C.
     "Genetic and molecular characterization of a gene encoding a wide
     specificity purine permease of Aspergillus nidulans reveals a novel
     family of transporters conserved in prokaryotes and eukaryotes."
     J. Biol. Chem. 270:8610-8622(1995).
     PubMed=7721763
[ 2] Andersen P.S., Frees D., Fast R., Mygind B.
     "Uracil uptake in Escherichia coli K-12: isolation of uraA mutants and
     cloning of the gene."
     J. Bacteriol. 177:2008-2013(1995).
     PubMed=7721693

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