{PDOC00867}
{PS01126; EF_TS_1}
{PS01127; EF_TS_2}
{BEGIN}
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* Elongation factor Ts signatures *
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In prokaryotes  elongation  factor Ts (EF-Ts) is a component of the elongation
cycle of  protein  biosynthesis.  It associates with the EF-Tu.GDP complex and
induces the  exchange  of  GDP to GTP, it remains bound to the aminoacyl-tRNA.
EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome [1].

EF-Ts is also a  component  of  the chloroplast protein biosynthetic machinery
and is encoded in the genome of some algal chloroplast [2]. It is also present
in mitochondria [3].

As signature patterns for EF-Ts, we  selected two conserved regions located in
the N-terminal part of the protein.

-Consensus pattern: L-R-x(2)-[ST]-[GSDNQ]-x-[GSA]-[LIVMF]-x(0,1)-[DENKAC]-x-K-
                    [KRNEQS]-[AV]-L
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Consensus pattern: [ELAS]-[LIVMF]-[NVCKGST]-[SCVA]-[QE]-T-D-[FS]-[VLA]-[SAT]-
                    [KRNLAQS]
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Last update: December 2004 / Pattern and text revised.

[ 1] Bubunenko M.G., Kireeva M.L., Gudkov A.T.
     "Novel data on interactions of elongation factor Ts."
     Biochimie 74:419-425(1992).
     PubMed=1637866
[ 2] Kostrzewa M., Zetsche K.
     "Organization of plastid-encoded ATPase genes and flanking regions
     including homologues of infB and tsf in the thermophilic red alga
     Galdieria sulphuraria."
     Plant Mol. Biol. 23:67-76(1993).
     PubMed=8219057
[ 3] Xin H., Woriax V.L., Burkhart W., Spremulli L.L.
     "Cloning and expression of mitochondrial translational elongation
     factor Ts from bovine and human liver."
     J. Biol. Chem. 270:17243-17249(1995).
     PubMed=7615523

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{END}