{PDOC00878}
{PS01141; T2SP_C}
{BEGIN}
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* Bacterial type II secretion system protein C signature *
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The secretion  pathway  (GSP) for the export of proteins (also called the type
II pathway)  [1] requires a number of protein components. One of them is known
as the  'C'  protein  and  has been sequenced in a variety of bacteria such as
Aeromonas (gene  exeC);  Erwinia  (gene  outC);  Escherichia coli (gene yheE);
Klebsiella pneumoniae  (gene  pulC);  Pseudomonas  aeruginosa  (gene  xcpS) or
Vibrio cholerae (gene epsC).

The size  of  the  'C' protein is around 270 to 300 amino acids. It apparently
contains a single transmembrane domain located in the N-terminal section.  The
short N-terminal  domain  is  predicted  to  be  cytoplasmic  and the large C-
terminal domain  periplasmic.  As a signature pattern, we selected a conserved
region in the C-terminal part of these proteins.

-Consensus pattern: P-x(6)-F-x(4)-[LF]-x(3)-D-[LIVM]-A-[LIVM]-x-[LIVM]-N-x-
                    [LIVMQ]-x-[LF]
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: December 2004 / Pattern and text revised.

[ 1] Salmond G.P.C., Reeves P.J.
     "Membrane traffic wardens and protein secretion in gram-negative
     bacteria."
     Trends Biochem. Sci. 18:7-12(1993).
     PubMed=8438237

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