{PDOC00879}
{PS01142; T2SP_N}
{BEGIN}
**********************************************************
* Bacterial type II secretion system protein N signature *
**********************************************************

The secretion  pathway  (GSP) for the export of proteins (also called the type
II pathway)  [1] requires a number of protein components. One of them is known
as the  'N'  protein  and  has been sequenced in a variety of bacteria such as
Aeromonas  (gene  exeN);  Erwinia  (gene outN);  Klebsiella  pneumoniae  (gene
pulN); or Vibrio cholerae (gene epsN).

The size of the  'N' protein is around 250 amino acids. It apparently contains
a single  transmembrane domain located in the N-terminal section. The short N-
terminal domain is predicted to be cytoplasmic and the large C-terminal domain
periplasmic. As  a signature pattern, we selected a conserved region in the N-
terminal part of these proteins.

-Consensus pattern: G-T-L-W-x-G-x(11)-L-x(4)-W
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: November 1995 / First entry.

[ 1] Salmond G.P.C., Reeves P.J.
     "Membrane traffic wardens and protein secretion in gram-negative
     bacteria."
     Trends Biochem. Sci. 18:7-12(1993).
     PubMed=8438237

--------------------------------------------------------------------------------
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and
distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives
(CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html
--------------------------------------------------------------------------------

{END}