{PDOC00888} {PS01153; NOL1_NOP2_SUN} {BEGIN} ********************************** * NOL1/NOP2/sun family signature * ********************************** The following proteins seems to be evolutionary related: - Mammalian proliferating-cell nucleolar antigen p120 (gene NOL1) which may play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation. - Yeast nucleolar protein NOP2 (or YNA1) which could be involved in nucleolar function during the onset of growth, and in the maintenance of nucleolar structure. - Yeast hypothetical protein YBL024w. - Bacterial protein sun (also known as fmu). - Escherichia coli hypothetical protein yebU. - Mycobacterium tuberculosis hypothetical protein MtCY21B4.24. - Methanococcus jannaschii hypothetical protein MJ0026. NOL1 is a protein of 855 residues, NOP2 consists of 618 residues, YBL024w of 684, sun is a protein of about 430 to 450 residues and MJ026 has 274 residues. They share a conserved central domain which contains some highly conserved regions. We have selected one these regions as a signature pattern. -Consensus pattern: [FV]-[DQ]-[KRA]-[LIVMA]-L-x-D-[AV]-P-C-[ST]-[GA] -Sequences known to belong to this class detected by the pattern: ALL. -Other sequence(s) detected in Swiss-Prot: NONE. -Last update: December 2004 / Pattern and text revised. -------------------------------------------------------------------------------- PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html -------------------------------------------------------------------------------- {END}