{PDOC00894}
{PS01161; GLC_GALNAC_ISOMERASE}
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* Glucosamine/galactosamine-6-phosphate isomerases signature *
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Glucosamine-6-phosphate isomerase (EC 3.5.99.6) (or Glc-6-P deaminase) is  the
enzyme responsible for the conversion of glucosamine 6-phosphate into fructose
6 phosphate [1].  It  is  the  last  specific  step  in  the  pathway  for  N-
acetylglucosamine (GlcNAC)  utilization  in  bacteria such as Escherichia coli
(gene nagB) or in fungi such as Candida albicans (gene NAG1).

Glc-6-P isomerase is evolutionary related to:

 - A putative Escherichia coli galactosamine-6-phosphate isomerase (gene agaI)
   [2].
 - Escherichia coli hypothetical protein yieK.
 - Bacillus subtilis hypothetical protein ybfT.

As a  signature  pattern we selected a conserved region located in the central
part  of these enzymes.  This region  contains a conserved histidine which has
been shown [1], in nagB, to be important for the pyranose ring-opening step of
the catalytic mechanism.

-Consensus pattern: [LIVM]-x(3)-[GNH]-x(0,1)-[LITCRV]-x-[LIVWF]-x-[LIVMF]-x-
                    [GS]-[LIVM]-G-x-[DENV]-G-[HN]
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: December 2004 / Pattern and text revised.

[ 1] Oliva G., Fontes M.R.M., Garratt R.C., Altamirano M.M., Calcagno M.L.,
     Horjales E.
     "Structure and catalytic mechanism of glucosamine 6-phosphate
     deaminase from Escherichia coli at 2.1 A resolution."
     Structure 3:1323-1332(1995).
     PubMed=8747459
[ 2] Reizer J., Ramseier T.M., Reizer A., Charbit A., Saier M.H. Jr.
     "Novel phosphotransferase genes revealed by bacterial genome
     sequencing: a gene cluster encoding a putative N-acetylgalactosamine
     metabolic pathway in Escherichia coli."
     Microbiology 142:231-250(1996).
     PubMed=8932697

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