{PDOC00915} {PS01189; RIBOSOMAL_S12E} {BEGIN} ************************************ * Ribosomal protein S12e signature * ************************************ A number of eukaryotic ribosomal proteins can be grouped on the basis of sequence similarities. One of these families consists of: - Vertebrate S12 [1]. - Trypanosoma brucei S12 [2]. - Caenorhabditis elegans S12 (F54E7.2). - Drosophila S12. - Fungi S12. These proteins have 130 to 150 amino acids. As a signature pattern, we selected a conserved region in the N-terminal part of these proteins. -Consensus pattern: [AS]-[LI]-[KREQP]-x(2)-[LIVM]-x(2)-[SA]-x(3)-[DNG]-G- [LIV]-x(2)-G-[LIV] -Sequences known to belong to this class detected by the pattern: ALL. -Other sequence(s) detected in Swiss-Prot: NONE. -Last update: December 2001 / Pattern and text revised. [ 1] Lin A., Chan Y.-L., Jones R., Wool I.G. "The primary structure of rat ribosomal protein S12. The relationship of rat S12 to other ribosomal proteins and a correlation of the amino acid sequences of rat and yeast ribosomal proteins." J. Biol. Chem. 262:14343-14351(1987). PubMed=3308890 [ 2] Marchal C., Ismaili N., Pays E. "A ribosomal S12-like gene of Trypanosoma brucei." Mol. Biochem. Parasitol. 57:331-334(1993). PubMed=8433721 -------------------------------------------------------------------------------- PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html -------------------------------------------------------------------------------- {END}