{PDOC00922}
{PS01199; RIBOSOMAL_L1}
{BEGIN}
**********************************
* Ribosomal protein L1 signature *
**********************************

Ribosomal protein L1  is the largest protein from the large ribosomal subunit.
In Escherichia  coli,  L1  is known to bind to the 23S rRNA. It  belongs  to a
family of  ribosomal proteins which, on the basis of sequence similarities [1,
2], groups:

 - Eubacterial L1.
 - Algal and plant chloroplast L1.
 - Cyanelle L1.
 - Archaebacterial L1.
 - Vertebrate L10A.
 - Yeast SSM1.

As a  signature  pattern, we selected the best conserved region located in the
central section  of these proteins. It is located at the end of an alpha helix
thought to be involved in RNA-binding.

-Consensus pattern: [IMGV]-x(2)-[LIVA]-x(2,3)-[LIVMY]-[GAS]-x(2)-[LMSF]-
                    [GSNH]-[PTKR]-[KRAVG]-[GN]-x-[LIMF]-P-[DENSTKQPRAGVI]
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: December 2004 / Pattern and text revised.

[ 1] Nikonov S., Nevskaya N., Eliseikina I., Fomenkova N., Nikulin A.,
     Ossina N., Garber M., Jonsson B.-H., Briand C., Al-Karadaghi S.,
     Svensson A., Aevarsson A., Liljas A.
     "Crystal structure of the RNA binding ribosomal protein L1 from
     Thermus thermophilus."
     EMBO J. 15:1350-1359(1996).
     PubMed=8635468
[ 2] Olvera J., Wool I.G.
     "The primary structure of rat ribosomal protein L10a."
     Biochem. Biophys. Res. Commun. 220:954-957(1996).
     PubMed=8607874

--------------------------------------------------------------------------------
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and
distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives
(CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html
--------------------------------------------------------------------------------

{END}