{PDOC00923}
{PS01200; TUB_1}
{PS01201; TUB_2}
{BEGIN}
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* Tub family signatures *
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The mouse  tubby mutation is  the  cause  of  maturity-onset  obesity, insulin
resistance and  sensory  deficits.  This  mutation  maps to a gene, tub [1,2],
which codes for a protein that belongs to a family which currently consists of
the following members:

 - Mammalian tub, an hydrophilic protein of about 500 residues, which could be
   involved in the hypothalamic regulation of body weight.
 - Human    protein   TULP1 [3] is involved in retinis pigmentosa 14 (RP14), a
   retinal degeneration disease.
 - Human protein TULP2 [3].
 - Mammalian protein TULP3 [4].
 - Mouse protein p4-6 whose function is not known.
 - Caenorhabditis elegans hypothetical protein F10B5.4.
 - Several fragmentary sequences from plants, Drosophila and human ESTs.

While the  N-terminal  part of these protein is not conserved in length nor in
the sequence,  the  C-terminal 250 residues are highly conserved. We therefore
selected two regions in the C-terminal part as signature patterns.  The second
region is  located  at  the  C-terminal  extremity  and contains a penultimate
cysteine residue  that  could  be  critical to the normal functioning of these
proteins.

-Consensus pattern: F-[KRHQ]-G-R-V-[ST]-x-A-S-V-K-N-F-Q
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Consensus pattern: A-F-[AG]-I-[GSAC]-[LIVM]-[ST]-S-F-x-[GST]-K-x-A-C-E
-Sequences known to belong to this class detected by the pattern: ALL,  except
 for TULP2.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Last update: December 2001 / Patterns and text revised.

[ 1] Kleyn P.W., Fan W., Kovats S.G., Lee J.J., Pulido J.C., Wu Y.,
     Berkemeier L.R., Misumi D.J., Holmgren L., Charlat O., Woolf E.A.,
     Tayber O., Brody T., Shu P., Hawkins F., Kennedy B., Baldini L.,
     Ebeling C., Alperin G.D., Deeds J., Lakey N.D., Culpepper J., Chen H.,
     Glucksmann-Kuis M.A., Carlson G.A., Duyk G.M., Moore K.J.
     "Identification and characterization of the mouse obesity gene tubby:
     a member of a novel gene family."
     Cell 85:281-290(1996).
     PubMed=8612280
[ 2] Noben-Trauth K., Naggert J.K., North M.A., Nishina P.M.
     Nature 380:534-538(1996).
[ 3] North M.A., Naggert J.K., Yan Y., Noben-Trauth K., Nishina P.M.
     "Molecular characterization of TUB, TULP1, and TULP2, members of the
     novel tubby gene family and their possible relation to ocular
     diseases."
     Proc. Natl. Acad. Sci. U.S.A. 94:3128-3133(1997).
     PubMed=9096357
[ 4] Nishina P.M., North M.A., Ikeda A., Yan Y., Naggert J.K.
     "Molecular characterization of a novel tubby gene family member,
     TULP3, in mouse and humans."
     Genomics 54:215-220(1998).
     PubMed=9828123

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{END}