{PDOC00938}
{PS01220; PBP}
{BEGIN}
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* Phosphatidylethanolamine-binding protein family signature *
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Mammalian phosphatidylethanolamine-binding   protein  (also  knowns  as  basic
cytosolic 21  Kd  protein)  is  a  186  residue  protein found in a variety of
tissues [1].  It  binds hydrophobic ligands, such as phosphatidylethanolamine,
but also  seems  [2]  to bind nucleotides such as GTP and FMN, it is suggested
that it could act in membrane  remodeling  during growth and maturation.  This
protein belongs to a family that also includes:

 - Drosophila antennal protein A5, a putative odorant-binding protein.
 - Onchocerca volvulus antigen Ov-16 and the related proteins D1, D2 and D3.
 - Plasmodium falciparum putative phosphatidylethanolamine-binding protein.
 - Toxocara  canis secreted antigen TES-26. This larval protein has been shown
   to bind phosphatidylethanolamine.
 - Yeast  protein  DKA1  (also  known  as  NSP1 or TFS1). The function of this
   protein is not very clear.
 - Yeast hypothetical protein YLR179C.
 - Caenorhabditis elegans hypothetical protein F40A3.3.
 - Plants proteins of the 'CENTRORADIALIS'  and "SELF-PRUNING' family, some of
   which seem to be involved in the flowering process.

As a signature pattern, we selected the best conserved region which is located
in the end of the first third of the sequence of these proteins.

-Consensus pattern: [FYL]-x-[LVM]-[LIVF]-x-[TIVM]-[DC]-P-D-x-P-[SNG]-x(10)-H
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Expert(s) to contact by email:
           Schoentgen F.; schoent@cnrs-orleans.fr

-Last update: December 2004 / Pattern and text revised.

[ 1] Seddiqi N., Bollengier F., Alliel P.M., Perin J.P., Bonnet F.,
     Bucquoy S., Jolles P., Schoentgen F.
     "Amino acid sequence of the Homo sapiens brain 21-23-kDa protein
     (neuropolypeptide h3), comparison with its counterparts from Rattus
     norvegicus and Bos taurus species, and expression of its mRNA in
     different tissues."
     J. Mol. Evol. 39:655-660(1994).
     PubMed=7807553
[ 2] Schoentgen F., Jolles P.
     "From structure to function: possible biological roles of a new
     widespread protein family binding hydrophobic ligands and displaying a
     nucleotide binding site."
     FEBS Lett. 369:22-26(1995).
     PubMed=7641877

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