{PDOC00944} {PS01228; COF_1} {PS01229; COF_2} {BEGIN} ************************************** * Hypothetical cof family signatures * ************************************** The following uncharacterized proteins have been shown [1] to share regions of similarities: - Escherichia coli protein cof. - Escherichia coli hypothetical protein ybhA. - Escherichia coli hypothetical protein yidA. - Escherichia coli hypothetical protein yigL and HI0597, the corresponding Haemophilus influenzae protein. - Bacillus subtilis hypothetical protein ycsE. - Bacillus subtilis hypothetical protein yxeH. - Haemophilus influenzae HI0003. - Mycoplasma genitalium hypothetical protein MG125. - Mycoplasma genitalium hypothetical protein MG263. - Mycoplasma genitalium hypothetical protein MG265. - Mycoplasma pneumoniae hypothetical protein A05_orf290. - Partial hypothetical proteins from Bacillus stearothermophilus and Mycoplasma capricolum. There are hydrophilic proteins of about 250 to 280 amino acid residues. We have developed two signature patterns for these proteins. -Consensus pattern: [LIVFYAN]-[LIVMFA]-x(2)-D-[LIVMF]-[ND]-G-T-[LIV]-[LVY]- [STANLM] -Sequences known to belong to this class detected by the pattern: ALL, except for A05_orf290. -Other sequence(s) detected in Swiss-Prot: 2. -Consensus pattern: [LIVMFC]-G-D-[GSANQ]-x-N-D-x(3)-[LIMFY]-x(2)-[AV]-x(2)- [GSCP]-x(2)-[LMP]-x(2)-[GAS] -Sequences known to belong to this class detected by the pattern: ALL, except for A05_orf290. -Other sequence(s) detected in Swiss-Prot: A number of cation E-type ATPases. -Last update: November 1997 / First entry. [ 1] Bairoch A., Rudd K.E. Unpublished observations (1996). -------------------------------------------------------------------------------- PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html -------------------------------------------------------------------------------- {END}