{PDOC00957} {PS01243; BI1} {BEGIN} ************************************ * Bax inhibitor-1 family signature * ************************************ Bax inhibitor-1 (BI-1) (gene TEGT) [1] is a suppressor of apoptosis that interacts with BCL2 and BCL-X. It is evolutionary related conserved and is found in all higher eukaryotes. It is also similar to the following proteins: - Escherichia coli hypothetical protein yccA and HI0044, the corresponding Haemophilus influenzae protein. - A probable Pseudomonas aeruginosa ortholog of yccA. These are proteins of about 25 Kd which seem to contain seven transmembrane domains. We developed a signature pattern that correspond to a region that starts with the beginning of the third transmembrane domain and ends in the middle of the fourth one. -Consensus pattern: G-x(2)-[LIVM]-[GC]-P-x-[LI]-x(4)-[SAGDT]-x(4,6)-[LIVM](2)- x(2)-A-x(2)-[MG]-T-x-[LIVM]-x-F -Sequences known to belong to this class detected by the pattern: ALL. -Other sequence(s) detected in Swiss-Prot: NONE. -Last update: April 2006 / Pattern revised. [ 1] Xu Q., Reed J.C. "Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast." Mol. Biol. Cell 1:337-346(1998). PubMed=9660918; -------------------------------------------------------------------------------- PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html -------------------------------------------------------------------------------- {END}