{PDOC00982}
{PS01276; PEPTIDASE_U32}
{BEGIN}
**********************************
* Peptidase family U32 signature *
**********************************

Porphyromonas gingivalis  collagenase  (gene  prtC)  [1]  is  an  enzyme  that
degrades type  I  collagen and that seems to require a metal cofactor. PrtC is
evolutionary related to a number of uncharacterized proteins:

 - Escherichia coli hypothetical protein ydcP.
 - Escherichia coli  hypothetical protein yegQ, and HI0419,  the corresponding
   Haemophilus influenzae protein.
 - Escherichia coli hypothetical protein yhbU.
 - Helicobacter pylori hypothetical protein HP0169.
 - Methanococcus jannaschii hypothetical protein MJ0090.

A well conserved region containing two cysteines can be used as a signature
pattern for these proteins.

-Consensus pattern: E-x-F-x(2)-G-[SA]-[LIVM]-C-x(4)-G-x-C-x-[LIVM]-S
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Note: These proteins belong to family U32 in the classification of peptidases
 [E1].

-Last update: November 1997 / First entry.

[ 1] Kato T., Takahashi N., Kuramitsu H.K.
     "Sequence analysis and characterization of the Porphyromonas
     gingivalis prtC gene, which expresses a novel collagenase activity."
     J. Bacteriol. 174:3889-3895(1992).
     PubMed=1317840
[E1] https://www.uniprot.org/docs/peptidas

--------------------------------------------------------------------------------
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and
distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives
(CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html
--------------------------------------------------------------------------------

{END}