{PDOC00983}
{PS01277; RIBONUCLEASE_PH}
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* Ribonuclease PH signature *
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Prokaryotic ribonuclease  PH  (EC 2.7.7.56) (RNase PH) [1] is a phosphorolytic
exoribonuclease that  removes  nucleotide residues following the -CCA terminus
of tRNA  and adds nucleotides to the ends of RNA molecules by using nucleoside
diphosphates as substrates.

RNase PH  is  a  conserved  protein  of  about  240 amino-acid residues. It is
evolutionary related to Caenorhabditis elegans hypothetical protein B0564.1.

As a signature pattern, we selected the most highly conserved region which is
located in the central part of these proteins.

-Consensus pattern: [CA]-[DE]-[LIVM](2)-[NQV]-[GTA]-D-[GA]-[SG]-x(2,3)-
                    [TAVLC]-[AT]
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: April 2006 / Pattern revised.

[ 1] Kelly K.O., Deutscher M.P.
     Characterization of Escherichia coli RNase PH."
     "J. Biol. Chem. 267:17153-17158(1992).
     PubMed=1512253

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