{PDOC00991}
{PS01289; TSC22}
{BEGIN}
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* TSC-22 / dip / bun family signature *
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The following eukaryotic proteins are evolutionary  related and are thought to
be involved in transcriptional regulation.

 - Vertebrate  protein  TSC-22  [1]. This protein of 144 residues seems to act
   a transcriptional regulator on C-type natriuretic peptide (CNP) promoter.
 - Mammalian  protein  DIP  (DSIP-immunoreactive peptide) [2], a protein of 77
   amino acids, whose function is not yet known.
 - Drosophila  protein  bunched [3] (gene bun) (also known as shortsighted), a
   probable transcription   factor  required  for  peripheral  nervous  system
   morphogenesis, eye development and oogenesis.
 - Caenorhabditis elegans hypothetical protein T18D3.7.

These proteins  are  highly  similar  in  a  region  of about 50 residues that
include a  conserved  leucine-zipper domain most probably involved in homo- or
hetero-dimerization. As  a  signature  pattern  we selected a highly conserved
stretch of residues that is located just in front of the leucine zipper.

-Consensus pattern: M-D-L-V-K-x-H-L-x(2)-A-V-R-E-E-V-E
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: November 1997 / First entry.

[ 1] Ohta S., Shimekake Y., Nagata K.
     "Molecular cloning and characterization of a transcription factor for
     the C-type natriuretic peptide gene promoter."
     Eur. J. Biochem. 242:460-466(1996).
     PubMed=9022669
[ 2] Vogel P., Maegert H.J., Cieslak A., Adermann K., Forssmann W.-G.
     "hDIP--a potential transcriptional regulator related to murine TSC-22
     and Drosophila shortsighted (shs)--is expressed in a large number of
     human tissues."
     Biochim. Biophys. Acta 1309:200-204(1996).
     PubMed=8982256
[ 3] Treisman J.E., Lai Z.C., Rubin G.M.
     "Shortsighted acts in the decapentaplegic pathway in Drosophila eye
     development and has homology to a mouse TGF-beta-responsive gene."
     Development 121:2835-2845(1995).
     PubMed=7555710

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