{PDOC00996} {PS51219; DPCK} {BEGIN} ********************************************** * Dephospho-CoA kinase (DPCK) domain profile * ********************************************** Dephospho-coenzyme A kinase (DPCK) (EC 2.7.1.24) catalyzes the final step in coenzyme A (CoA) biosynthesis, the phosphorylation of the 3'-hydroxyl group of ribose using ATP as a phosphate donor. DPCK is present in a wide range of organisms, including bacteria, fungi, plants and animals. Whereas bacterial DPCK is found in stand-alone form, mammalian DPCK is associated with another enzyme of the CoA biosynthetic pathway, phosphopantetheine adenylyltransferase (PPAT) (EC 2.7.7.3), in bifunctional coenzyme A synthase (CoA synthase) [1,2]. The DPCK domain contains an ATP/GTP-binding Walker A motif (P-loop) (see ) in its N-terminal extremity. It is structurally similar to many nucleoside kinases and other P-loop-containing nucleotide triphosphate hydrolases, despite having negligible sequence similarity to these enzymes. The DPCK domain consists of five parallel beta-strands flanked by alpha- helices (see ) [1,2]. The profile we developed covers the entire DPCK domain. -Sequences known to belong to this class detected by the profile: ALL. -Other sequence(s) detected in Swiss-Prot: NONE. -Last update: June 2006 / Pattern removed, profile added and text revised. [ 1] Obmolova G., Teplyakov A., Bonander N., Eisenstein E., Howard A.J., Gilliland G.L. "Crystal structure of dephospho-coenzyme A kinase from Haemophilus influenzae." J. Struct. Biol. 136:119-125(2001). PubMed=11886213; DOI=10.1006/jsbi.2001.4428 [ 2] O'Toole N., Barbosa J.A.R.G., Li Y., Hung L.-W., Matte A., Cygler M. "Crystal structure of a trimeric form of dephosphocoenzyme A kinase from Escherichia coli." Protein Sci. 12:327-336(2003). PubMed=12538896 -------------------------------------------------------------------------------- PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html -------------------------------------------------------------------------------- {END}