{PDOC00999} {PS01297; FLAP_GST2_LTC4S} {BEGIN} ************************************ * FLAP/GST2/LTC4S family signature * ************************************ The following mammalian proteins are evolutionary related [1]: - Leukotriene C4 synthase (EC 4.4.1.20) (gene LTC4S), an enzyme that catalyzes the production of LTC4 from LTA4. - Microsomal glutathione S-transferase II (EC 2.5.1.18) (GST-II) (gene GST2), an enzyme that can also produces LTC4 fron LTA4. - 5-lipoxygenase activating protein (gene FLAP), a protein that seems to be required for the activation of 5-lipoxygenase. These are proteins of 150 to 160 residues that contain three transmembrane segments. As a signature pattern, we selected a conserved region between the first and second transmembrane domains. -Consensus pattern: G-x(3)-F-E-R-V-[FY]-x-A-[NQ]-x-N-C -Sequences known to belong to this class detected by the pattern: ALL. -Other sequence(s) detected in Swiss-Prot: NONE. -Last update: November 1997 / First entry. [ 1] Jakobsson P.-J., Mancini J.A., Ford-Hutchinson A.W. "Identification and characterization of a novel human microsomal glutathione S-transferase with leukotriene C4 synthase activity and significant sequence identity to 5-lipoxygenase-activating protein and leukotriene C4 synthase." J. Biol. Chem. 271:22203-22210(1996). PubMed=8703034 -------------------------------------------------------------------------------- PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html -------------------------------------------------------------------------------- {END}