{PDOC01000}
{PS01298; DAPB}
{BEGIN}
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* Dihydrodipicolinate reductase signature *
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Dihydrodipicolinate reductase  (EC  1.3.1.26) catalyzes the second step in the
biosynthesis of  diaminopimelic  acid  and  lysine,  the NAD or NADP-dependent
reduction of 2,3-dihydrodipicolinate into 2,3,4,5-tetrahydrodipicolinate. This
enzyme is present in bacteria (gene dapB) and higher plants.

As a  signature  pattern we selected the best conserved region in this enzyme.
It is  located  in  the  central  section and is part of the substrate-binding
region [1].

-Consensus pattern: [ERND]-[IVL]-x-[ED]-x-H-x(3)-K-x-[DE]-x(2)-S-[GA]-[TAS]-
                    [ALCGS]
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: December 2004 / Pattern and text revised.

[ 1] Scapin G., Blanchard J.S., Sacchettini J.C.
     "Three-dimensional structure of Escherichia coli dihydrodipicolinate
     reductase."
     Biochemistry 34:3502-3512(1995).
     PubMed=7893645

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{END}