{PDOC01002} {PS50058; G_PROTEIN_GAMMA} {BEGIN} *********************************** * G-protein gamma subunit profile * *********************************** Guanine nucleotide-binding proteins (G proteins) [1] act as intermediaries in the transduction of signals generated by transmembrane receptors. G proteins consist of three subunits (alpha, beta, and gamma). The alpha subunit binds to and hydrolyzes GTP; the functions of the beta and gamma subunits are less clear but they seem to be required for the replacement of GDP by GTP as well as for membrane anchoring and receptor recognition. The gamma subunits are small proteins (from 70 to 110 residues) that are bound to the membrane via a isoprenyl group (either a farnesyl or a geranyl- geranyl) covalently linked to their C-terminus. In mammals there are at least 12 different isoforms of gamma subunits. The Caenorhabditis elegans protein egl-10, which is a regulator of G-protein signalling, contains a G-protein gamma-like domain. We have developed a profile that spans the complete length of the gamma subunit. -Sequences known to belong to this class detected by the profile: ALL, except for yeast and squid G-protein gamma. -Other sequence(s) detected in Swiss-Prot: NONE. -Expert(s) to contact by email: Pennington S.R.; srpenn@liverpool.ac.uk -Last update: November 1997 / First entry. [ 1] Pennington S.R. Protein Prof. 2:16-315(1995). -------------------------------------------------------------------------------- PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html -------------------------------------------------------------------------------- {END}