{PDOC01019} {PS01315; CDS} {BEGIN} ************************************************ * Phosphatidate cytidylyltransferase signature * ************************************************ Phosphatidate cytidylyltransferase (EC 2.7.7.41) [1,2,3] (also known as CDP- diacylglycerol synthase) (CDS) is the enzyme that catalyzes the synthesis of CDP-diacylglycerol from CTP and phosphatidate (PA). CDP-diacylglycerol is an important branch point intermediate in both prokaryotic and eukaryotic organisms. CDS is a membrane-bound enzyme. As a signature pattern we selected a conserved region located in the C-terminal part. -Consensus pattern: S-x-[LIVMF]-K-R-x(4)-K-D-x-[GSA]-x(2)-[LIF]-[PGS]-x-H-G-G- [LIVMF]-x-D-R-[LIVMFT]-D -Sequences known to belong to this class detected by the pattern: ALL. -Other sequence(s) detected in Swiss-Prot: NONE. -Last update: December 2004 / Pattern and text revised. [ 1] Sparrow C.P., Raetz C.R.H. "Purification and properties of the membrane-bound CDP-diglyceride synthetase from Escherichia coli." J. Biol. Chem. 260:12084-12091(1985). PubMed=2995359 [ 2] Shen H., Heacock P.N., Clancey C.J., Dowhan W. "The CDS1 gene encoding CDP-diacylglycerol synthase in Saccharomyces cerevisiae is essential for cell growth." J. Biol. Chem. 271:789-795(1996). PubMed=8557688 [ 3] Saito S., Goto K., Tonosaki A., Kondo H. "Gene cloning and characterization of CDP-diacylglycerol synthase from rat brain." J. Biol. Chem. 272:9503-9509(1997). PubMed=9083091 -------------------------------------------------------------------------------- PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html -------------------------------------------------------------------------------- {END}