{PDOC01022}
{PS01318; TSAA_1}
{PS51668; TSAA_2}
{BEGIN}
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* TsaA-like domain signature and profile *
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The following uncharacterized proteins have  been shown [1] to be evolutionary
related and to contain a tsaA-like domain:

 - Escherichia  coli  hypothetical  protein yaeB and HI0510, the corresponding
   Haemophilus influenzae protein.
 - Agrobacterium tumefaciens Ti plasmid protein virR.
 - Pseudomonas aeruginosa protein rcsF.
 - Archaeoglobus fulgidus hypothetical protein AF0241.
 - Archaeoglobus fulgidus hypothetical protein AF0433.
 - Methanococcus jannaschii hypothetical protein MJ1583.
 - Methanobacterium thermoautotrophicum hypothetical protein MTH1797.

These are  proteins of from 120 to 240 amino-acid residues (with the exception
of AF0433  which  is  366  residues  long).  Although  found  predominantly in
prokaryotes the  tsaA-like  domain  is  also  found  in plants, Drosophila and
mammals (human, rat, mouse and others):

 - Mammalian Nef-associated protein 1 (NAP1).

The structure  of  the  tsaA-like domain contains a six-stranded anti-parallel
beta-barrel (see    <PDB:2NV4>).    The   tsaA-like   domain   may   bind   S-
adenosylmethionine (AdoMet) and possesses a methyltransferase activity [2].

As a  signature  pattern we selected a conserved region in the central part of
the domain.  We  also  developed  a  profile  that covers the entire tsaA-like
domain.

-Consensus pattern: G-[AV]-F-[STA]-x-R-[SA]-x(2)-R-P-N
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Last update: February 2013 / Text revised; profile added.

[ 1] Bairoch A.
     Unpublished observations (1998).
[ 2] Forouhar F., Kuzin A., Seetharaman J., Lee I., Zhou W., Abashidze M.,
     Chen Y., Yong W., Janjua H., Fang Y., Wang D., Cunningham K., Xiao R.,
     Acton T.B., Pichersky E., Klessig D.F., Porter C.W., Montelione G.T.,
     Tong L.
     "Functional insights from structural genomics."
     J. Struct. Funct. Genomics 8:37-44(2007).
     PubMed=17588214; DOI=10.1007/s10969-007-9018-3

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