{PDOC01030}
{PS01327; MSCL}
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* Large-conductance mechanosensitive channels mscL family signature *
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Mechanosensitive ion  channels  play  a  critical role in transducing physical
stresses at  the  cell  membrane into an electrochemical response. Prokaryotes
harbor a  large-conductance  mechanosensitive channel (gene mscL) [1] which is
opened by  membrane  stretch  force  and  may participate in the regulation of
osmotic pressure changes within the cell.

MscL is  a  protein  of  about  15  kD.  It  forms  a  channel  organized as a
homopentamer [2], with each subunit containing two transmembrane regions.

As a  signature  pattern, we selected the best conserved region. It is located
in the N-terminal region. It starts three residues before the beginning of the
first transmembrane domain and ends in the middle of that domain.

-Consensus pattern: [KR]-G-N-[LIVM](2)-D-[LIVM]-A-[LIVM]-[GA]-[LIVM](3)-G
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: April 2006 / Pattern revised.

[ 1] Moe P.C., Blount P., Kung C.
     "Functional and structural conservation in the mechanosensitive
     channel MscL implicates elements crucial for mechanosensation."
     Mol. Microbiol. 28:583-592(1998).
     PubMed=9632260
[ 2] Chang G., Spencer R.H., Lee A.T., Barclay M.T., Rees D.C.
     "Structure of the MscL homolog from Mycobacterium tuberculosis: a
     gated mechanosensitive ion channel."
     Science 282:2220-2226(1998).
     PubMed=9856938

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