{PDOC01032} {PS01329; COX6A} {BEGIN} ********************************************** * Cytochrome c oxidase subunit VIa signature * ********************************************** Cytochrome c oxidase (EC 1.9.3.1) [1] is an oligomeric enzymatic complex which is a component of the respiratory chain complex and is involved in the transfer of electrons from cytochrome c to oxygen. In eukaryotes this enzyme complex is located in the mitochondrial inner membrane; in aerobic prokaryotes it is found in the plasma membrane. In addition to the three large subunits that form the catalytic center of the enzyme complex there are, in eukaryotes, a variable number of small polypeptidic subunits. One of these subunits is known as VIa in vertebrates and fungi. Mammals have two tissue-specific isoforms of VIa, a liver and a heart form. Only one form is found is fish [2]. A signature pattern for VIa was developed that is based on the best conserved part of the protein, a region located in its C-terminal section. -Consensus pattern: [LIV]-R-x-K-x-[FYW]-x-W-[GS]-D-G-x-[KH]-[ST]-x-F-x-N -Sequences known to belong to this class detected by the pattern: ALL. -Other sequence(s) detected in Swiss-Prot: NONE. -Last update: July 1999 / First entry. [ 1] Capaldi R.A., Malatesta F., Darley-Usmar V.M. "Structure of cytochrome c oxidase." Biochim. Biophys. Acta 726:135-148(1983). PubMed=6307356 [ 2] Huttemann M., Exner S., Arnold S., Lottspeich F., Kadenbach B. "The cDNA sequences of cytochrome c oxidase subunit VIa from carp and rainbow trout suggest the absence of isoforms in fishes." Biochim. Biophys. Acta 1319:14-18(1997). PubMed=9107314 -------------------------------------------------------------------------------- PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html -------------------------------------------------------------------------------- {END}