{PDOC01039}
{PS01337; ODC_AZ}
{BEGIN}
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* Ornithine decarboxylase antizyme signature *
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Ornithine decarboxylase  antizyme  (ODC-AZ)  [1]  binds  to, and destabilizes,
ornithine decarboxylase  (ODC),  a  key  enzyme in polyamine synthesis. ODC is
then rapidly degraded. The expression of ODC-AZ requires programmed, ribosomal
frameshifting which  is  modulated  according to the cellular concentration of
polyamines.  High levels of polyamines induce a +1 ribosomal frameshift in the
translation of  mRNA  for  the  antizyme  leading to the expression of a full-
length protein.

At least  three forms  of ODC-AZ exist in mammals [2] and the protein has been
found in  Drosophila  (protein  Gutfeeling), nematodes and Schizosaccharomyces
pombe [3].

As a  signature  pattern,  we  selected  a  highly  conserved region in the C-
terminal part of these proteins.

-Consensus pattern: [LT]-L-E-[FY]-[AVC]-[DE]-[DE]-[KNQHT]-[LMT]
-Sequences known to belong to this class detected by the pattern: ALL,  except
 for S.pombe.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: December 2001 / Pattern and text revised.

[ 1] Matsufuji S., Matsufuji T., Miyazaki Y., Murakami Y., Atkins J.F.,
     Gesteland R.F., Hayashi S.-I.
     "Autoregulatory frameshifting in decoding mammalian ornithine
     decarboxylase antizyme."
     Cell 80:51-60(1995).
     PubMed=7813017
[ 2] Ivanov I.P., Rohrwasser A., Terreros D.A., Gesteland R.F., Atkins J.F.
     "Discovery of a spermatogenesis stage-specific ornithine decarboxylase
     antizyme: antizyme 3."
     Proc. Natl. Acad. Sci. U.S.A. 97:4808-4813(2000).
     PubMed=10781085; DOI=10.1073/pnas.070055897
[ 3] Ivanov I.P., Matsufuji S., Murakami Y., Gesteland R.F., Atkins J.F.
     "Conservation of polyamine regulation by translational frameshifting
     from yeast to mammals."
     EMBO J. 19:1907-1917(2000).
     PubMed=10775274; DOI=10.1093/emboj/19.8.1907

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