{PDOC01041} {PS01339; SURF4} {BEGIN} ************************** * SURF4 family signature * ************************** The surfeit locus 4 gene (SURF4 or surf-4) encodes for a conserved integral eukaryotic membrane protein of about 270 to 300 amino-acid residues that seems to be located in the endoplasmic reticulum [1]. As a signature pattern, we selected a conserved region located in the C-terminal section and that seems to overlap with the beginning of the last transmembrane domain of these proteins. -Consensus pattern: [KR]-Y-[DE]-F-[FY]-Q-x(2)-S-x-[LIVM]-G-G-L-L -Sequences known to belong to this class detected by the pattern: ALL. -Other sequence(s) detected in Swiss-Prot: NONE. -Last update: July 1999 / First entry. [ 1] Reeves J.E., Fried M. "The surf-4 gene encodes a novel 30 kDa integral membrane protein." Mol. Membr. Biol. 12:201-208(1995). PubMed=7540914 -------------------------------------------------------------------------------- PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html -------------------------------------------------------------------------------- {END}