{PDOC01048}
{PS01350; ISPF}
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* 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase signature *
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The bacterial  ispF protein [1] catalyzes the fifth step of the deoxyxylulose-
5-phosphate pathway    (DXP)  of  isoprenoid  biosynthesis;  the conversion of
4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate     into    2C-methyl-D-
erythritol 2,4-cyclodiphosphate   and   CMP.   It   can   also   converts   4-
diphosphocytidyl-2C-methyl-D-erythritol into    2C-methyl-D-erythritol    3,4-
cyclophosphate and CMP.

In addition to bacterial ispF, this family also includes:

 - Plasmodium falciparum hypothetical protein PfB0420W.

These are  proteins  of  around  20 kDa whose sequence is well conserved. As a
signature  pattern, we  selected  a  well  conserved  region located in the N-
terminal part of these proteins.

-Consensus pattern: S-[DN]-[GA]-D-[LIVAP]-[LIVAG]-x-H-[STAC]-x(2)-[DNT]-[SAG]-
                    x(2)-[SGA]
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: April 2006 / Pattern revised.

[ 1] Rohdich F., Wungsintaweekul J., Fellermeier M., Sagner S., Herz S.,
     Kis K., Eisenreich W., Bacher A., Zenk M.H.
     "Cytidine 5'-triphosphate-dependent biosynthesis of isoprenoids: YgbP
     protein of Escherichia coli catalyzes the formation of
     4-diphosphocytidyl-2-C-methylerythritol."
     Proc. Natl. Acad. Sci. U.S.A. 96:11758-11763(1999).
     PubMed=10518523;

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