{PDOC01050} {PS01352; HEMATOPO_REC_L_F1} {BEGIN} ************************************************************** * Long hematopoietin receptor, single chain family signature * ************************************************************** A number of receptors for lymphokines, hematopoietic growth factors and growth hormone-related molecules have been found to share a common binding domain. These receptors are designated as hematopoietin receptors [1,2] and the corresponding ligands as hematopoietins. Further, hematopoietins have been subdivided into two major structural groups: Large/long and small/short hematopoietins. Several receptor chains for large hematopoietins are structurally related such that their extracellular parts strictly contain the 200 amino-acids hematopoietin domain, duplicated in the thrombopoietin receptor and in avian prolactin receptors. This subgroup of receptor chains contains: - Growth hormone receptor (GHR). - Prolactin receptor (PRLR). - Erythropoietin receptor (EPOR). - Thrombopoietin receptor (TPOR). A schematic representation of the structure of these receptors is shown below: +----------------------------------------xxxxxxx-------------------------+ | C C C C Extracellular XXXXXXX Cytoplasmic | +-|-|-------|--|-------------------------xxxxxxx-------------------------+ | | | | Transmembrane +-+ +--+ These receptor chains are single components of receptors that homodimerize upon binding of the cognate cytokine, following the structural model described for the growth hormone-receptor complex [3]. We have used one pattern to detect this family. The motif is located in the carboxy-terminal part of the 200 amino acid hematopoietin domain. -Consensus pattern: [LIV]-x-[LIV]-x-W-x(12,16)-Y-[EQ]-[LIV]-x(25,27)-L-x(10)- [RKH]-x-[RKH]-x(5,9)-[FYW]-x(2)-[FYW]-x(5)-[LIV] -Sequences known to belong to this class detected by the pattern: ALL -Other sequence(s) detected in Swiss-Prot: NONE. -Expert(s) to contact by email: Boulay J.-L.; Jean-Louis.Boulay@unibas.ch -Last update: December 2001 / First entry. [ 1] Boulay J.-L., Paul W.E. "Hematopoietin sub-family classification based on size, gene organization and sequence homology." Curr. Biol. 3:573-581(1993). PubMed=15335670 [ 2] Sprang S.R., Bazan J.F. Current Opin. Struct. Biol. 3:815-827(1993). [ 3] de Vos A.M., Ultsch M., Kossiakoff A.A. "Human growth hormone and extracellular domain of its receptor: crystal structure of the complex." Science 255:306-312(1992). PubMed=1549776; -------------------------------------------------------------------------------- PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html -------------------------------------------------------------------------------- {END}