{PDOC50128} {PS50128; SURP} {BEGIN} ***************************** * SURP motif repeat profile * ***************************** The SURP motif is an about 40-residue module, which has been named after the first proteins containing it (suppressor-of-white-apricot and PRP21/SPP91). It is found tandemly repeated in proteins involved in either constitutive or regulated pre-mRNA splicing. Overall, the N-terminal half of the SURP motif exhibits a higher conservation than the C-terminal half, where length differences are apparent in addition to sequence heterogeneity. Nevertheless, within this region, the motif F-x-F-L and the dipeptide Y-Y at the C-terminal border are conserved in nearly all proteins. The function of the SURP motif is still unknown [1,2,3,4]. Some proteins known to contain a SURP motif are listed below: - Drosophila suppressor-of-white-apricot (su(wa)) protein. It modulates a specific set of somatic, sex-independent pre-mRNA processing events. - Yeast PRP21/SPP91, a constitutive pre-mRNA splicing factor. - Vertebrate SWAP proteins, which are homologs of the su(wa) protein. - Mammalian SF3a120 splicing factor, the homolog of PRP21/SPP91. The profile we developed covers the entire SURP motif. -Sequences known to belong to this class detected by the profile: ALL. -Other sequence(s) detected in Swiss-Prot: NONE. -Last update: January 2003 / First entry. [ 1] Spikes D.A., Kramer J., Bingham P.M., Van Doren K. "SWAP pre-mRNA splicing regulators are a novel, ancient protein family sharing a highly conserved sequence motif with the prp21 family of constitutive splicing proteins." Nucleic Acids Res. 22:4510-4519(1994). PubMed=7971282 [ 2] Denhez F., Lafyatis R. "Conservation of regulated alternative splicing and identification of functional domains in vertebrate homologs to the Drosophila splicing regulator, suppressor-of-white-apricot." J. Biol. Chem. 269:16170-16179(1994). PubMed=8206918 [ 3] Kraemer A., Mulhauser F., Wersig C., Groening K., Bilbe G. RNA 1:260-272(1995). [ 4] Rain J.-C., Tartakoff A.M., Kraemer A., Legrain P. "Essential domains of the PRP21 splicing factor are implicated in the binding to PRP9 and PRP11 proteins and are conserved through evolution." RNA 2:535-550(1996). PubMed=8718683 -------------------------------------------------------------------------------- PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html -------------------------------------------------------------------------------- {END}