{PDOC50189} {PS50189; NTR} {BEGIN} ********************** * NTR domain profile * ********************** The netrin (NTR) module is an about 130-residue domain found in the C- terminal parts of netrins, complement proteins C3, C4, and C5, secreted frizzled-related proteins, and type I procollagen C-proteinase enhancer proteins (PCOLCEs), as well as in the N-terminal parts of tissue inhibitors of metalloproteinases (TIMPs) (see ). The proteins harboring the NTR domain fulfill diverse biological roles ranging from axon guidance, regulation of Wnt signalling, to the control of the activity of metalloproteinases. The NTR domain can be found associated to other domains such as CUB (see ), WAP (see ), Kazal (see ), Kunitz (see ), Ig-like (see ), laminin N-terminal, laminin-type EGF (see ) or frizzled (see ). The NTR domain is implicated in inhibition of zinc metalloproteinases of the metzincin family [1,2]. The NTR module is a basic domain containing six conserved cysteines, which are likely to form internal disulfide bonds, and several conserved blocks of hydrophobic residues (including an YLLLG-like motif). The NTR module consists of a beta-barrel with two terminal alpha-helices packed side by side against the face of the beta-barrel (see ) [1]. The profile we developed covers the entire NTR domain. -Sequences known to belong to this class detected by the profile: ALL. -Other sequence(s) detected in Swiss-Prot: NONE. -Last update: November 2003 / First entry. [ 1] Banyai L., Patthy L. "The NTR module: domains of netrins, secreted frizzled related proteins, and type I procollagen C-proteinase enhancer protein are homologous with tissue inhibitors of metalloproteases." Protein Sci. 8:1636-1642(1999). PubMed=10452607 [ 2] Trexler M., Banyai L., Patthy L. "A human protein containing multiple types of protease-inhibitory modules." Proc. Natl. Acad. Sci. U.S.A. 98:3705-3709(2001). PubMed=11274388; DOI=10.1073/pnas.061028398 -------------------------------------------------------------------------------- PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html -------------------------------------------------------------------------------- {END}