{PDOC50225}
{PS50225; SOCS}
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* SOCS box domain profile *
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The SOCS  box domain was first identified in SH2-domain-containing proteins of
the suppressor  of  cytokines  signaling (SOCS) family [1] but was latter also
found in:

 - The WSB (WD-40-repeat-containing proteins with a SOCS box) family,
 - The SSB (SPRY domain-containing proteins with a SOCS box) family,
 - The ASB (Ankyrin-repeat-containing proteins with a SOCS box) family,
 - The RAR (GTPase domain and SOCS box-containing proteins) family [2].

The SOCS  box found in these proteins is a C-terminal domain of about 50 amino
acids composed of two blocks of well-conserved residues separated by between 2
to 10    nonconserved    residues  [2].  The  C-terminal conserved region is a
Leu/Pro-rich sequence  of  unknown  function, whereas the N-terminal conserved
region is called a 'BC box' [3] and binds to the elongin BC complex [3,4].  It
has been  proposed  that  this  association could couple bound proteins to the
ubiquitination or proteasomal compartments [4].

Some proteins known to contain a SOCS box domain are listed below:

 - Mammalian  cytokine-inducible  SH2-containing  (CIS)  protein. This protein
   belongs to  the  SOCS  family and inhibits erythropoietin and interleukin 3
   receptor signaling  by competing with signaling molecules such as STATs for
   binding to phosphorylated receptor cytoplasmic domains.
 - Mammalian   SOCS-1  protein.  This  protein  is  a  negative  regulator  of
   interleukin 6 signaling. It acts by binding to and inhibiting the catalytic
   activity of members of the JAK family of cytoplasmic kinases.
 - Vertebrate WSB-1.

The profile we developed covers the entire SOCS box domain.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: May 2002 / First entry.

[ 1] Starr R., Willson T.A., Viney E.M., Murray L.J.L., Rayner J.R.,
     Jenkins B.J., Gonda T.J., Alexander W.S., Metcalf D., Nicola N.A.,
     Hilton D.J.
     "A family of cytokine-inducible inhibitors of signalling."
     Nature 387:917-921(1997).
     PubMed=9202125; DOI=10.1038/43206;
[ 2] Hilton D.J., Richardson R.T., Alexander W.S., Viney E.M.,
     Willson T.A., Sprigg N.S., Starr R., Nicholson S.E., Metcalf D.,
     Nicola N.A.
     "Twenty proteins containing a C-terminal SOCS box form five structural"
     Proc. Natl. Acad. Sci. U.S.A. 95:114-119(1998).
     PubMed=9419338;
[ 3] Kamura T., Sato S., Haque D., Liu L., Kaelin W.G. Jr., Conaway R.C.,
     Conaway J.W.
     "The Elongin BC complex interacts with the conserved SOCS-box motif
     present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat
     families."
     Genes Dev. 12:3872-3881(1998).
     PubMed=9869640;
[ 4] Zhang J.G., Farley A., Nicholson S.E., Willson T.A., Zugaro L.M.,
     Simpson R.J., Moritz R.L., Cary D., Richardson R., Hausmann G.,
     Kile B.J., Kent S.B.H., Alexander W.S., Metcalf D., Hilton D.J.,
     Nicola N.A., Baca M.
     "The conserved SOCS box motif in suppressors of cytokine signaling
     binds to elongins B and C and may couple bound proteins to proteasomal
     degradation."
     Proc. Natl. Acad. Sci. U.S.A. 96:2071-2076(1999).
     PubMed=10051596;

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