{PDOC50827} {PS50827; DDT} {BEGIN} ********************** * DDT domain profile * ********************** The DDT has been named after the better characterized DNA-binding homeobox- containing proteins and the Different Transcription and chromatin remodeling factors in which it is found. It is a domain of about 60 amino acids which is exclusively associated with nuclear domains like AT-Hook (see ), PHD finger (see ), methyl-CpG-binding domain, bromodomain (see ) and DNA-binding homeodomain (see ). The DDT domain is characterized by a number of conserved aromatic and charged residues and is predicted to consist of three alpha helices. A DNA-binding function for the DDT domain has been proposed [1]. Proteins known to contain a DDT domain are listed below: - Bromodomain PHD finger transcription factors (BPTFs) from Caenorhabditis elegans, Drosophila and human. The human protein FALZ or FAC1 is believed to play arole in Alzheimer's disease. - Chromatin remodeling factors of the BAZ (bromodomain adjacent to zinc finger proteins)-family from Caenorhabditis elegans, Drosophila and human. The human BAZ protein WSTF is implicated in Wiliams Syndrome, a complex developmental disorder with multisystemic defects. - Homeodomain-containing proteins from Arabidopsis thaliana. - Hypothetical PHD-domain-containing protein from Arabidopsis thaliana. The profile we developed covers the entire DDT domain. -Sequences known to belong to this class detected by the profile: ALL. -Other sequence(s) detected in Swiss-Prot: NONE. -Note: The DDT domain was first identified in the BAZ family as part of a larger LH (Leucine-rich Helical) domain [2]. -Last update: September 2003 / First entry. [ 1] Doerks T., Copley R., Bork P. "DDT -- a novel domain in different transcription and chromosome remodeling factors." Trends Biochem. Sci. 26:145-146(2001). PubMed=11246006 [ 2] Jones M.H., Hamana N., Nezu J.I., Shimane M. "A novel family of bromodomain genes." Genomics 63:40-45(2000). PubMed=10662543; DOI=10.1006/geno.1999.6071 -------------------------------------------------------------------------------- PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html -------------------------------------------------------------------------------- {END}