{PDOC50828}
{PS50828; SMR}
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* Smr domain profile *
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The Smr domain is an around 90-residue domain found in:

 - The C-terminal region of the mutS2 proteins from bacteria and plants,
 - The small mutS related (smr) proteins from bacteria and eukaryotes.

These proteins  could  be  involved in mismatch repair (MMR) or/and chromosome
crossing-over and  segregation.  It has been proposed that the Smr domain acts
as a nicking endonuclease [1,2].

The profile we developed spans the entire Smr domain.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: March 2004 / First entry.

[ 1] Moreira D., Philippe H.
     "Smr: a bacterial and eukaryotic homologue of the C-terminal region of
     the MutS2 family."
     Trends Biochem. Sci. 24:298-300(1999).
     PubMed=10431172
[ 2] Malik H.S., Henikoff S.
     "Dual recognition-incision enzymes might be involved in mismatch
     repair and meiosis."
     Trends Biochem. Sci. 25:414-418(2000).
     PubMed=10973051

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