{PDOC50836} {PS50836; DOMON} {BEGIN} ************************ * DOMON domain profile * ************************ The DOMON domain is an 110-125 residue long domain which has been identified in the physiologically important enzyme dopamine beta-monooxygenase and in several other secreted and transmembrane proteins from both plants and animals. It has been named after DOpamine beta-MOnooxygenase N-terminal domain. The DOMON domain can be found in one to four copies and in association with other domains, such as the Cu-ascorbate dependent monooxygenase domain, the epidermal growth factor domain (see ), the trypsin inhibitor- like domain (TIL), the SEA domain (see ), and the Reelin domain. The architectures of the DOMON domain proteins strongly suggest a function in extracellular adhesion [1,2]. The sequence conservation is predominantly centered around patches of hydrophobic residues. The secondary structure prediction of the DOMON domain points to an all-beta-strand fold with seven or eight core strands supported by a buried core of conserved hydrophobic residues. There is a characteristic motif with two small positions (Gly or Ser) corresponding to a conserved turn immediately C-terminal to strand three. It has been proposed that the DOMON domain might form a beta-sandwich structure, with the strands distributed into two beta sheets as is seen in many extracellular adhesion domains such as the immunoglobulin, fibronectin type-III, cadherin and PKD (see ) domains [1]. Some proteins known to contain a DOMON domain are listed below: - Mammalian dopamine beta-monooxygenase (DM). It is involved in the conversion of dopamine to the catecholamine noradrenaline, a crucial physiological modulator of the sympathetic nervous system, T-cell-mediated immunity and fetal development. - Drosophila tyramine-beta-hydroxylase (TBH), an orthologue of DM. It is needed for the biosynthesis of the neurotransmitter octopamine from tyramine. - Human brain protein C9orf4. - Mouse SDR2 protein. - Botryllus schlosseri PAR protein, a soluble immunoglobulin molecule homologue. - Caenorhabditis elegans uncharacterized protein C09F9.2. - Arabidopsis thaliana uncharacterized protein At5g54830. The profile we developed covers the entire DOMON domain. -Sequences known to belong to this class detected by the profile: ALL. -Other sequence(s) detected in Swiss-Prot: NONE. -Last update: November 2003 / Profile revised. [ 1] Aravind L. "DOMON: an ancient extracellular domain in dopamine beta-monooxygenase and other proteins." Trends Biochem. Sci. 26:524-526(2001). PubMed=11551777 [ 2] Ponting C.P. "Domain homologues of dopamine beta-hydroxylase and ferric reductase: roles for iron metabolism in neurodegenerative disorders?" Hum. Mol. Genet. 10:1853-1858(2001). PubMed=11532994 -------------------------------------------------------------------------------- PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html -------------------------------------------------------------------------------- {END}