{PDOC50859} {PS50859; LONGIN} {BEGIN} ************************* * Longin domain profile * ************************* The longin domain is an about 110-residue domain found at the N-terminus of numerous proteins, that structurally and (possibly) functionally defines a novel family of vesicle-associated memmbrane proteins (VAMPs) called long VAMPs or longins. The longin domain is associated to a C-terminal domain, which is strongly homologous to the synaptobrevin domain of brevins. Longins are common to yeast, protists, animals and plants. Wide distribution of the longin domain throughout eukaryotes suggests a generic but very important function. It has been proposed that the longin domain might be involved in the regulation of membrane fusion [1]. The profile we developed covers the entire longin domain. -Sequences known to belong to this class detected by the profile: ALL. -Other sequence(s) detected in Swiss-Prot: NONE. -Expert(s) to contact by email: Filippini F.; francesco.filippini@unipd.it -Last update: July 2003 / First entry. [ 1] Filippini F., Rossi V., Galli T., Budillon A., D'Urso M., D'Esposito M. "Longins: a new evolutionary conserved VAMP family sharing a novel SNARE domain." Trends Biochem. Sci. 26:407-409(2001). PubMed=11440841; -------------------------------------------------------------------------------- PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html -------------------------------------------------------------------------------- {END}