{PDOC50870}
{PS50870; AH}
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* Arfaptin homology (AH) domain profile *
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The arfaptin  homology domain (AH) is an about 210-residue region of homology,
which has  been  identified between PICK1 and arfaptins [1]. The AH domain can
be found  alone  or  in  association  with  other  domains  such  as  PDZ (see
<PDOC50106>) [1].  The AH domain of arfaptin has been shown to dimerize and to
bind Arf and Rho family GTPases [2,3].

The resolution  of  arfaptin  has  shown  that the AH domain consists of three
alpha-helices arranged  as  an extended antiparallel alpha-helical bundle. Two
arfaptin AH  domains  associate  to  form  a highly elongated, crescent-shaped
dimer (see <PDB:1I49>) [2,3].

Some proteins known to contain an AH domain are listed below:

 - Animal protein kinase C-binding protein PICK1.
 - Animal arfaptin 1 and 2. Arfaptins are effectors of two G proteins, Rac and
   Arf (ADP-ribosylation factor).
 - Mammalian 69 kDa islet cell autoantigen (ICA69) [4]. It is likely to play a
   role in  membrane  trafficking  at the Golgi complex and immature secretory
   granules in neurosecretory cells.

The profile we developed covers the entire AH domain.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: November 2003 / First entry.

[ 1] Takeya R., Takeshige K., Sumimoto H.
     "Interaction of the PDZ domain of human PICK1 with class I
     ADP-ribosylation factors."
     Biochem. Biophys. Res. Commun. 267:149-155(2000).
     PubMed=10623590; DOI=10.1006/bbrc.1999.1932
[ 2] Tarricone C., Xiao B., Justin N., Walker P.A., Rittinger K.,
     Gamblin S.J., Smerdon S.J.
     "The structural basis of Arfaptin-mediated cross-talk between Rac and
     Arf signalling pathways."
     Nature 411:215-219(2001).
     PubMed=11346801; DOI=10.1038/35075620
[ 3] Cherfils J.
     "Structural mimicry of DH domains by Arfaptin suggests a model for the
     recognition of Rac-GDP by its guanine nucleotide exchange factors."
     FEBS Lett. 507:280-284(2001).
     PubMed=11696355
[ 4] Spitzenberger F., Pietropaolo S., Verkade P., Habermann B.,
     Lacas-Gervais S., Mziaut H., Pietropaolo M., Solimena M.
     "Islet cell autoantigen of 69 kDa is an arfaptin-related protein
     associated with the Golgi complex of insulinoma INS-1 cells."
     J. Biol. Chem. 278:26166-26173(2003).
     PubMed=12682071; DOI=10.1074/jbc.M213222200

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