{PDOC50903}
{PS50903; RUBREDOXIN_LIKE}
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* Rubredoxin-like domain profile *
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The rubredoxin-like  domain  is a 45- to 55-residue domain containing one iron
atom tetrahedrally coordinated to four cysteinyl residues (Fe(S-Cys)4 center).
It is involved in electron transfer processes [1,2].

The most  conserved  feature  of  the rubredoxin-like domain is the cluster of
four cysteines  involved  in  iron binding (Cys-x-x-Cys-x(n)-Cys-x-x-Cys) [2].
Structure analyses of several rubredoxin-like domains have shown that they are
folded into  a  short  three-stranded  antiparallel beta-sheet and a number of
loops (see <PDB:1RDG>) [3,4,5,6].

Proteins known to contain a rubredoxin-like domain are listed below:

 - Rubredoxin   (Rd),  a  small  electron-transfer  prokaryotic  protein  (see
   <PDOC00179>).
 - Rubrerythrin  (Rr),  a  non-heme  protein  isolated from anaerobic sulfate-
   reducing bacteria.
 - Flavorubredoxin,   a   bacterial   protein  involved  in  elctron  transfer
   processes.
 - Nigerythrin, a prokaryotic protein of unknown function.

The profile we developed covers the entire rubredoxin-like domain.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: March 2003 / First entry.

[ 1] van Beeumen J.J., van Driessche G., Liu M.-Y., LeGall J.
     J. Biol. Chem. 266:20645-20653(1991).
[ 2] Prickril B.C., Kurtz D.M. Jr., LeGall J., Voordouw G.
     "Cloning and sequencing of the gene for rubrerythrin from
     Desulfovibrio vulgaris (Hildenborough)."
     Biochemistry 30:11118-11123(1991).
     PubMed=1932032
[ 3] Frey M., Sieker L., Payan F., Haser R., Bruschi M., Pepe G.,
     LeGall J.
     "Rubredoxin from Desulfovibrio gigas. A molecular model of the
     oxidized form at 1.4 A resolution."
     J. Mol. Biol. 197:525-541(1987).
     PubMed=3441010
[ 4] Day M.W., Hsu B.T., Joshua-Tor L., Park J.-B., Zhou Z.H., Adams M.W.W.,
     Rees D.C.
     "X-ray crystal structures of the oxidized and reduced forms of the
     rubredoxin from the marine hyperthermophilic archaebacterium
     Pyrococcus furiosus."
     Protein Sci. 1:1494-1507(1992).
     PubMed=1303768
[ 5] Sieker L.C., Stenkamp R.E., LeGall J.
     "Rubredoxin in crystalline state."
     Methods Enzymol. 243:203-216(1994).
     PubMed=7830611
[ 6] deMare F., Kurtz D.M. Jr., Nordlund P.
     "The structure of Desulfovibrio vulgaris rubrerythrin reveals a unique
     combination of rubredoxin-like FeS4 and ferritin-like diiron
     domains."
     Nat. Struct. Biol. 3:539-546(1996).
     PubMed=8646540

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