{PDOC50908} {PS50908; RWD} {BEGIN} ********************** * RWD domain profile * ********************** The RWD domain is a conserved region of about 110 amino acid residues, which has been identified in the mouse GCN2 eIF2alpha kinase and histidyl-tRNA synthetase and in presumed orthologs in other eukaryotic species from yeast to vertebrates. Additionally, it is also found in WD repeat containing proteins, yeast DEAD (DEXD)-like helicases, many RING-finger containing proteins, the UPF0029 uncharacterized protein family (see ) and a range of hypothetical proteins. The RWD domain has been named after the better characterized RING finger (see ) and WD repeat containing proteins (see ) and DEAD-like helicaces (see ). It has been proposed that the RWD domain might have a function in protein interaction [1]. The RWD domain is predicted to have an alpha/beta secondary structure and is thought to be related to ubiquitin-conjugating enzymes (UBCc) domain, although the catalytic cysteine critical for ubiquitin-conjugating activity is not conserved in most members of the novel subfamily [1]. The profile we developed covers the entire RWD domain. -Sequences known to belong to this class detected by the profile: ALL. -Other sequence(s) detected in Swiss-Prot: NONE. -Last update: May 2003 / First entry. [ 1] Doerks T., Copley R.R., Schultz J., Ponting C.P., Bork P. "Systematic identification of novel protein domain families associated with nuclear functions." Genome Res. 12:47-56(2002). PubMed=11779830; DOI=10.1101/ -------------------------------------------------------------------------------- PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html -------------------------------------------------------------------------------- {END}