{PDOC50969}
{PS50969; FCP1}
{BEGIN}
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* FCP1 homology domain profile *
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Yeast FCP1    is   an  essential protein serine phosphatase (EC 3.1.3.16) that
dephosphorylates the  C-terminal  domain  (CTD)  of  RNA  polymerase  II. FCP1
orthologs are  present in all known eukaryote proteomes. The N-terminal domain
of FCP1  corresponds  to  the  catalytic  unit of the phosphatase and has been
refered to  as  the FCP1 homology domain. The FCP1 homology domain, which is a
~180-residue module, is also found in many other proteins of unknown function.
It contains   a   DxDx(T/V)   motif  preceded  by  four  hydrophobic  residues
characteristic of  a  large  family  of  metal-dependent phosphohydrolases and
phosphotransferases.  The  first aspartate residue  is  likely  to participate
in catalysis,  whereas  the  second could have a role in substrate recognition
[1,2,3,4].

The profile we developed covers the entire FCP1 homology domain.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: March 2004 / First entry.

[ 1] Archambault J., Chambers R.S., Kobor M.S., Ho Y., Cartier M.,
     Bolotin D., Andrews B., Kane C.M., Greenblatt J.
     "An essential component of a C-terminal domain phosphatase that
     interacts with transcription factor IIF in Saccharomyces cerevisiae."
     Proc. Natl. Acad. Sci. U.S.A. 94:14300-14305(1997).
     PubMed=9405607
[ 2] Kobor M.S., Archambault J., Lester W., Holstege F.C.P., Gileadi O.,
     Jansma D.B., Jennings E.G., Kouyoumdjian F., Davidson A.R.,
     Young R.A., Greenblatt J.
     "An unusual eukaryotic protein phosphatase required for transcription
     by RNA polymerase II and CTD dephosphorylation in S. cerevisiae."
     Mol. Cell 4:55-62(1999).
     PubMed=10445027
[ 3] Hausmann S., Shuman S.
     "Defining the active site of Schizosaccharomyces pombe C-terminal
     domain phosphatase Fcp1."
     J. Biol. Chem. 278:13627-13632(2003).
     PubMed=12556522; DOI=10.1074/jbc.M213191200
[ 4] Cho H., Kim T.-K., Mancebo H., Lane W.S., Flores O., Reinberg D.
     "A protein phosphatase functions to recycle RNA polymerase II."
     Genes Dev. 13:1540-1552(1999).
     PubMed=10385623

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